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pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can lower panobinostat degrees by ~70% and bring on treatment method failure.pentobarbital will reduce the level or impact of ethotoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch